1. Gall stones ( 90% patients with carcinoma GB have gall stones. size of stone has a direct relationship with development of carcinoma , the risk is ten times more for larger stones (3 cm in diameter ) than for stones less than 1 cm in diameter. Risk is higher with symptomatic than asymptomatic stones ).
2. Adenomatous gall bladder polyps ( particularly polyps larger than 10mm )
3. Calcified ( procelain ) Gall bladder
4. Choledochal cyst
6. Anomalous pancreaticobiliary duct junction
7. Exposure to carcinogens like azotoulene and nitrosamine
8. Typhoid carriers
9. Sclerosing cholangitis
10. Cholecystoenteric fistula
11. Ulcerative colitis
*ASI surgery mentions two other risk factors which are chemicals used in rubber industry and use of adulterated mustard cooking oil in India .