1 - benign prostatic hypertrophy ( BPH ) mcqs

Question 1
Hyperplastic growth that characterises benign prostatic hyperplasia occurs in which of the following anatomical zones of the prostate?
Central
Peripheral
Transitional--------------
Posterior

Question 2
Benign prostatic hyperplasia is hyperplasia of:
Prostatic epithelium
Smooth muscle in the prostate
Connective tissue in the prostate
All the above------------

Question 3
All the following statements are false except:
PSA is an ideal tumor marker for benign prostatic hyperplasia.
PSA is an ideal tumor marker for prostate cancer.
PSA cannot discriminate well between benign prostatic hyperplasia and prostate cancer-------------
PSA can discriminate well between benign prostatic hyperplasia and prostate cancer

Question 4
Which of the following receptors are present in high concentration in the prostate?
Cholinergic receptors
α adrenoceptor----------
β adrenoceptor
All the above

Question 5
With regards to Tamsulosin, all the following statements are true except:
It is a subtype selectiveα1 receptor antagonist
It has greater affinity for prostatic smooth muscles than vascular smooth muscles
It can be initiated at therapeutic doses without need for dose titration
It is given twice daily---------------

Question 6
Finasteride is used:
In symptomatic benign prostatic hyperplasia patients with prostate volume ≥40ml.----------------
For a maximum period of 6 months
In patients requiring rapid relief of symptoms
All the above statements are true

Question 7
Minimum duration for which Finasteride should be given for beneficial effect in benign prostatic hyperplasia is:
2 months
6 months-----------
9 months
12 months

Question 8
To interpret PSA levels of a patient on dutasteride for 6 months or more, multiply the obtained laboratory value by:
0.5
2-----------
2.5
4

Question 9
Which of this drug decreases the size of the prostate?
Doxazocin
Tamsulosin
Dutasteride---------
Alfuzosin

Question 10
Tamsulosin can be combined with which cardiovascular drug?
β blocker
Calcium antagonist
ACE inhibitor
Any of the above--------------

Question 11
Dutasteride acts by:
Inhibiting 5 alpha reductase enzymes type 1 and type 2------------
Antagonising alpha adrenergic receptors
Blocking androgen receptors
All of the above

Question 12
Dose of Dutasteride should be used with caution in:
Elderly patients
Renal impairment
Hepatic impairment----------
None of the above

Question 13
Which of the following statements is not correct?
Combination therapy with 5 alpha reductase inhibitor and α receptor antagonist in benign prostatic hyperplasia
Is safe
Is more effective than either drug used alone
Reduces the long term risk of acute urinary retention
Cannot be used in combination----------------

Question 14
Which of the following drug should not be handled by pregnant women due to the potential for development of foetal anomaly?
Dutasteride------------
Tamsulosin
Doxazocin
None of the above

Question 15
Which of these statements is not true?
Transurethral resection of the prostate (TURP) is recommended in patients with renal failure secondary to benign prostate hyperplasia
Transurethral resection of the prostate (TURP) is recommended in patients in whom prostate gland is smaller than 30 ml-------------
One of the complication of Transurethral resection of the prostate (TURP) is retrograde ejaculation
Transurethral resection of the prostate (TURP) increases the peak flow rate of urine